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Overlevingskans slokdarmcarcinoom
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Voor het slagen van immuuntherapie dienen strategieën bedacht te worden die deze mechanismen ongedaan maken en tegelijk antitumor immuunresponsen opwekken. Men vertrekt van de hypothese dat emgs in combinatie met immuuntherapie een nieuwe complementaire strategie vormen voor kankerbehandeling. De resultaten van dit project zullen aangewend worden voor het opstellen van de in vivo validatie van de immuun-modulerende eigenschap- pen van emgs en voor het opstellen van optimale combinaties met bestaande immuuntherapieën voor klinische toepassingen.

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Daarnaast voorziet het project een evaluatie van braf v600 mutant circulerend tumor dna als predictieve merker. Lien de beck, onderzoek naar de immunomodulerende eigenschappen van epigenetische modulerende geneesmiddelen (EMGs) in multipel myeloom en melanoom. Het omzeilen van het immuunsysteem is een belangrijk kenmerk van kankercellen.

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Beurzen 2017, startersbeurzen. Gil Awada, bRAF/mek-inhibitor rechallenge in combinatie met de autofagie-inhibitor hydroxychloroquine bij patiënten met metastatisch braf v600 mutant melanoom. Bedrag:.500 euro, looptijd: 12 maanden, promotor: prof. Preklinische studies toonden aan dat autofagie belangrijk is in braf v600 mutante kankers. Gebaseerd hierop wordt een fase 2-studie opgestart, waarbij patiënten die een progressieve ziekte vertonen na behandeling met een braf-inhibitor met/zonder mek-inhibitor en immuun checkpoint inhibitoren een rechallenge ondergaan met de inhibitoren dabrafenib/trametinib en de farmacologische autofagie-inhibitor hydroxychloroquine of placebo, waarbij de veiligheid, de doeltreffendheid.

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